The European Association for Clinical Pharmacology and Therapeutics and the Journal Basic & Clinical Pharmacology & Toxicology

Clinical pharmacology and therapeutics.

Clinical Pharmacology and Therapeutics

Pharmacology and Toxicology of Leflunomide

Leflunomide (LEF), used for rheumatoid arthritis, inhibits dihydro-orotate dehydrogenase (DHODH) and tyrosine kinase (TK) enzymes and has anti-inflammatory, lymphocyte proliferation regulatory, immunosuppression and chondroprotective effects. The most common adverse effects are gastrointestinal disorders, weight loss, hypertension, skin infection, and neurological and hematological toxicity. It...

Clinical pharmacology and toxicology of dichloroacetate.

Dichloroacetate (DCA) is a xenobiotic of interest to both environmental toxicologists and clinicians. The chemical is a product of water chlorination and of the metabolism of various drugs and industrial chemicals. Its accumulation in groundwater and at certain Superfund sites is considered a potential health hazard. However, concern about DCA toxicity is predicated mainly on data obtained in i...

The relationship between the components of clinical pharmacology curriculum and nursing students' clinical skills

Introduction: The present study was conducted with the aim of determining the relationship between the components of clinical pharmacology curriculum and clinical skills of nursing students. Methods: The statistical population of this descriptive cross-sectional study includes nursing students of the Bandar Abbas School of Midwifery Nursing. Samples were collected by census. The data based on ...